Assay Detail
Binding
CHEMBL908982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Src kinase
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.72 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218549 | — | — | 1 | 8.22 |
| CHEMBL436137 | — | — | 1 | 8.15 |
| CHEMBL221742 | — | — | 1 | 8.05 |
| CHEMBL218656 | — | — | 1 | 8.00 |
| CHEMBL218102 | — | — | 1 | 8.00 |
| CHEMBL221236 | — | — | 1 | 7.68 |
| CHEMBL220931 | — | — | 1 | 7.58 |
| CHEMBL434578 | — | — | 1 | 7.50 |
| CHEMBL220929 | — | — | 1 | 7.44 |
| CHEMBL375433 | — | — | 1 | 7.40 |
| CHEMBL221582 | — | — | 1 | 7.40 |
| CHEMBL218386 | — | — | 1 | 7.39 |
| CHEMBL221431 | — | — | 1 | 6.96 |
| CHEMBL217961 | — | — | 1 | 6.89 |
| CHEMBL221975 | — | — | 1 | 6.89 |
| CHEMBL218281 | — | — | 1 | 6.89 |
| CHEMBL446951 | — | — | 1 | 6.86 |
| CHEMBL218597 | — | — | 1 | 6.85 |
| CHEMBL220798 | — | — | 1 | 6.85 |
| CHEMBL218742 | — | — | 1 | 6.75 |
| CHEMBL220912 | — | — | 1 | 6.62 |
| CHEMBL436516 | — | — | 1 | 6.50 |
| CHEMBL374248 | — | — | 1 | 6.39 |
| CHEMBL218049 | — | — | 1 | 6.32 |
| CHEMBL220480 | — | — | 1 | 6.02 |
| CHEMBL218317 | — | — | 1 | 5.82 |
| CHEMBL218042 | — | — | 1 | 5.82 |
| CHEMBL218598 | — | — | 1 | 5.75 |
| CHEMBL374002 | — | — | 1 | 5.66 |
| CHEMBL218072 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218549 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL436137 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL221742 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL218656 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL218102 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL221236 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL220931 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL434578 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL220929 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL375433 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL221582 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL218386 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL221431 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL218281 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL221975 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL217961 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL446951 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL218597 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL220798 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL218742 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL220912 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL436516 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL374248 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL218049 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL220480 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL218317 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL218042 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL218598 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL374002 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL218072 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL385112 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL218177 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL218003 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL384877 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL218842 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL218551 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL441545 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL374868 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL218738 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL221739 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL218411 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL376052 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL218160 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL376860 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL218109 | — | IC50 | > | 50000.0 | nM | - |