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Assay Detail

CHEMBL909003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to EP4 receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin E2 receptor EP4 subtype (CHEMBL1836)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Comparison between two classes of selective EP(3) antagonists and their biological activities.
Belley M, Chan CC, Gareau Y, Gallant M, Juteau H, Houde K, Lachance N, Labelle M, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Gordon R, Chauret N, Li C, Zamboni RJ, Metters KM.
Bioorg Med Chem Lett (2006) 16 : 5639 -5642
PubMed 16931013 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.80 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220820 1 6.36
CHEMBL1237317 1 6.21
CHEMBL218626 1 6.21
CHEMBL217988 1 6.21
CHEMBL385955 1 6.08
CHEMBL218280 1 6.08
CHEMBL218071 1 6.05
CHEMBL218179 1 6.02
CHEMBL218178 1 6.02
CHEMBL218228 1 6.00
CHEMBL218229 1 6.00
CHEMBL220821 1 6.00
CHEMBL217991 1 5.96
CHEMBL220802 1 5.89
CHEMBL385396 1 5.82
CHEMBL384878 1 5.82
CHEMBL218123 1 5.70
CHEMBL376053 1 5.70
CHEMBL376282 1 5.36
CHEMBL1237315 1 5.36
CHEMBL219590 1 5.21
CHEMBL1237316 1 5.21
CHEMBL217941 1 5.10
CHEMBL423815 1 4.89
CHEMBL218263 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220820 Ki = 440.0 nM 6.36
CHEMBL1237317 Ki = 610.0 nM 6.21
CHEMBL218626 Ki = 610.0 nM 6.21
CHEMBL217988 Ki = 620.0 nM 6.21
CHEMBL385955 Ki = 840.0 nM 6.08
CHEMBL218280 Ki = 840.0 nM 6.08
CHEMBL218071 Ki = 890.0 nM 6.05
CHEMBL218179 Ki = 960.0 nM 6.02
CHEMBL218178 Ki = 960.0 nM 6.02
CHEMBL218228 Ki = 1000.0 nM 6.00
CHEMBL218229 Ki = 1000.0 nM 6.00
CHEMBL220821 Ki = 1000.0 nM 6.00
CHEMBL217991 Ki = 1100.0 nM 5.96
CHEMBL220802 Ki = 1300.0 nM 5.89
CHEMBL385396 Ki = 1500.0 nM 5.82
CHEMBL384878 Ki = 1500.0 nM 5.82
CHEMBL218123 Ki = 2000.0 nM 5.70
CHEMBL376053 Ki = 2000.0 nM 5.70
CHEMBL376282 Ki = 4400.0 nM 5.36
CHEMBL1237315 Ki = 4400.0 nM 5.36
CHEMBL219590 Ki = 6200.0 nM 5.21
CHEMBL1237316 Ki = 6200.0 nM 5.21
CHEMBL217941 Ki = 8000.0 nM 5.10
CHEMBL423815 Ki = 13000.0 nM 4.89
CHEMBL218263 Ki > 15000.0 nM -