Assay Detail
Functional
CHEMBL909145
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Antimicrobial activity against Naegleria fowleri Lee (M67) at day 3
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Naegleria fowleri |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synergistic activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.13 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 8.51 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 18.3 | nM | 7.74 |