Assay Detail
Functional
CHEMBL909342
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Antibacterial activity against Klebsiella pneumoniae assessed as LPS neutralisation by LAL assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Klebsiella pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.09 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220590 | — | — | 1 | 7.10 |
| CHEMBL218563 | — | — | 1 | 6.52 |
| CHEMBL268572 | — | — | 1 | 6.40 |
| CHEMBL386394 | — | — | 1 | 6.30 |
| CHEMBL218635 | — | — | 1 | 6.30 |
| CHEMBL415180 | — | — | 1 | 6.05 |
| CHEMBL386609 | — | — | 1 | 6.00 |
| CHEMBL439876 | — | — | 1 | 6.00 |
| CHEMBL376022 | — | — | 1 | 6.00 |
| CHEMBL221186 | OTX-008 | 1.0 | 1 | 5.82 |
| CHEMBL220485 | — | — | 1 | 5.82 |
| CHEMBL436771 | — | — | 1 | 5.68 |
| CHEMBL221949 | — | — | 1 | 5.68 |
| CHEMBL221950 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220590 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL218563 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL268572 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL386394 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL218635 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL415180 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL386609 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL439876 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL376022 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL221186 | OTX-008 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL220485 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL436771 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL221949 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL221950 | — | IC50 | = | 2400.0 | nM | 5.62 |