Assay Detail
Functional
CHEMBL909346
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Antibacterial activity against Serratia marcescens assessed as LPS neutralisation by LAL assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Serratia marcescens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.50 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218563 | — | — | 1 | 5.82 |
| CHEMBL218635 | — | — | 1 | 5.50 |
| CHEMBL220485 | — | — | 1 | 5.47 |
| CHEMBL436771 | — | — | 1 | 5.38 |
| CHEMBL386394 | — | — | 1 | 5.35 |
| CHEMBL221186 | OTX-008 | 1.0 | 1 | - |
| CHEMBL386609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218563 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL218635 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL220485 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL436771 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL386394 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL221186 | OTX-008 | IC50 | > | 5000.0 | nM | - |
| CHEMBL386609 | — | IC50 | > | 5000.0 | nM | - |