Assay Detail
Binding
CHEMBL909359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat 11beta-HSD1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL2391) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.06 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375341 | — | — | 1 | 8.52 |
| CHEMBL375156 | — | — | 1 | 8.40 |
| CHEMBL219142 | — | — | 1 | 8.22 |
| CHEMBL374728 | — | — | 1 | 7.89 |
| CHEMBL217917 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375341 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL375156 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL219142 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL374728 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL217917 | — | Ki | = | 52.0 | nM | 7.28 |