Assay Detail
Functional
CHEMBL909397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
9
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.34 |
| EC50 | 3 | 7.90 | 8.34 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407198 | — | — | 3 | 8.34 |
| CHEMBL414087 | — | — | 3 | 7.80 |
| CHEMBL375360 | — | — | 3 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407198 | — | IC50 | = | 4.571 | nM | 8.34 |
| CHEMBL407198 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL414087 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL414087 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL375360 | — | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL375360 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL414087 | — | Emax | = | 11.0 | — | - |
| CHEMBL375360 | — | Emax | = | 16.0 | — | - |
| CHEMBL407198 | — | Emax | = | 22.0 | — | - |