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Assay Detail

CHEMBL909462

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Binding
Inhibition of human supersomes MAOB
ChEMBL ↗
62
Total Activities
62
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] B (CHEMBL2039) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Impact of species-dependent differences on screening, design, and development of MAO B inhibitors.
Novaroli L, Daina A, Favre E, Bravo J, Carotti A, Leonetti F, Catto M, Carrupt PA, Reist M.
J Med Chem (2006) 49 : 6264 -6272
PubMed 17034132 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 7.81 9.04
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL108697 — — 1 9.04
CHEMBL142799 — — 1 9.04
CHEMBL111309 — — 1 8.97
CHEMBL356977 — — 1 8.96
CHEMBL145292 — — 1 8.95
CHEMBL142582 — — 1 8.95
CHEMBL109085 — — 1 8.92
CHEMBL348922 — — 1 8.86
CHEMBL18966 — — 1 8.86
CHEMBL356714 — — 1 8.85
CHEMBL274030 — — 1 8.83
CHEMBL276076 — — 1 8.81
CHEMBL108660 — — 1 8.80
CHEMBL357614 — — 1 8.79
CHEMBL111310 — — 1 8.78
CHEMBL145781 7-BENZYLOXYCOUMARIN — 1 8.77
CHEMBL146222 — — 1 8.75
CHEMBL342327 — — 1 8.71
CHEMBL109018 — — 1 8.67
CHEMBL145792 — — 1 8.63
CHEMBL145503 — — 1 8.49
CHEMBL145003 — — 1 8.44
CHEMBL142916 — — 1 8.41
CHEMBL143555 — — 1 8.37
CHEMBL339626 — — 1 8.34
CHEMBL125921 — — 1 8.30
CHEMBL127983 — — 1 8.27
CHEMBL127622 — — 1 8.25
CHEMBL127982 — — 1 8.20
CHEMBL439811 — — 1 8.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL108697 — IC50 = 0.912 nM 9.04
CHEMBL142799 — IC50 = 0.912 nM 9.04
CHEMBL111309 — IC50 = 1.072 nM 8.97
CHEMBL356977 — IC50 = 1.096 nM 8.96
CHEMBL145292 — IC50 = 1.122 nM 8.95
CHEMBL142582 — IC50 = 1.122 nM 8.95
CHEMBL109085 — IC50 = 1.202 nM 8.92
CHEMBL348922 — IC50 = 1.38 nM 8.86
CHEMBL18966 — IC50 = 1.38 nM 8.86
CHEMBL356714 — IC50 = 1.413 nM 8.85
CHEMBL274030 — IC50 = 1.479 nM 8.83
CHEMBL276076 — IC50 = 1.549 nM 8.81
CHEMBL108660 — IC50 = 1.585 nM 8.80
CHEMBL357614 — IC50 = 1.622 nM 8.79
CHEMBL111310 — IC50 = 1.66 nM 8.78
CHEMBL145781 7-BENZYLOXYCOUMARIN IC50 = 1.698 nM 8.77
CHEMBL146222 — IC50 = 1.778 nM 8.75
CHEMBL342327 — IC50 = 1.95 nM 8.71
CHEMBL109018 — IC50 = 2.138 nM 8.67
CHEMBL145792 — IC50 = 2.344 nM 8.63
CHEMBL145503 — IC50 = 3.236 nM 8.49
CHEMBL145003 — IC50 = 3.631 nM 8.44
CHEMBL142916 — IC50 = 3.89 nM 8.41
CHEMBL143555 — IC50 = 4.266 nM 8.37
CHEMBL339626 — IC50 = 4.571 nM 8.34
CHEMBL125921 — IC50 = 5.012 nM 8.30
CHEMBL127983 — IC50 = 5.37 nM 8.27
CHEMBL127622 — IC50 = 5.623 nM 8.25
CHEMBL127982 — IC50 = 6.31 nM 8.20
CHEMBL439811 — IC50 = 7.943 nM 8.10
CHEMBL338094 — IC50 = 8.128 nM 8.09
CHEMBL124935 — IC50 = 8.318 nM 8.08
CHEMBL127774 — IC50 = 8.511 nM 8.07
CHEMBL142738 — IC50 = 8.71 nM 8.06
CHEMBL127517 — IC50 = 10.96 nM 7.96
CHEMBL340701 — IC50 = 14.79 nM 7.83
CHEMBL18978 — IC50 = 15.85 nM 7.80
CHEMBL339565 — IC50 = 26.3 nM 7.58
CHEMBL125843 — IC50 = 26.3 nM 7.58
CHEMBL126505 — IC50 = 31.62 nM 7.50
CHEMBL339027 — IC50 = 33.11 nM 7.48
CHEMBL127751 — IC50 = 42.66 nM 7.37
CHEMBL125094 — IC50 = 42.66 nM 7.37
CHEMBL143316 — IC50 = 57.54 nM 7.24
CHEMBL434695 — IC50 = 64.57 nM 7.19
CHEMBL125044 — IC50 = 74.13 nM 7.13
CHEMBL339429 — IC50 = 117.49 nM 6.93
CHEMBL342724 — IC50 = 125.89 nM 6.90
CHEMBL421088 — IC50 = 177.83 nM 6.75
CHEMBL127518 — IC50 = 190.55 nM 6.72