Assay Detail
Functional
CHEMBL909613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of cytokine withdrawal protection in IL3 dependent Bcl2 overexpressing mouse FL5.12 cells in presence of bovine gelatin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.33 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 8.10 |
| CHEMBL376410 | — | — | 1 | 7.89 |
| CHEMBL384218 | — | — | 1 | 7.60 |
| CHEMBL217960 | — | — | 1 | 7.57 |
| CHEMBL218524 | — | — | 1 | 7.57 |
| CHEMBL218408 | — | — | 1 | 7.48 |
| CHEMBL376409 | — | — | 1 | 7.17 |
| CHEMBL384217 | — | — | 1 | 6.34 |
| CHEMBL266944 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL376410 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL384218 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL217960 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL218524 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL218408 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL376409 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL384217 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL266944 | — | EC50 | = | 530.0 | nM | 6.28 |