Assay Detail
Functional
CHEMBL909614
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Reversal of cytokine withdrawal protection in IL3 dependent Bcl2 overexpressing mouse FL5.12 cells in presence of 3% FBS
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.10 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.30 |
| CHEMBL376410 | — | — | 1 | 6.77 |
| CHEMBL376409 | — | — | 1 | 6.44 |
| CHEMBL384218 | — | — | 1 | 6.41 |
| CHEMBL217960 | — | — | 1 | 6.18 |
| CHEMBL218408 | — | — | 1 | 5.96 |
| CHEMBL374309 | — | — | 1 | 5.89 |
| CHEMBL218524 | — | — | 1 | 5.72 |
| CHEMBL384217 | — | — | 1 | 5.48 |
| CHEMBL192571 | — | — | 1 | 4.89 |
| CHEMBL266944 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL376410 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL376409 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL384218 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL217960 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL218408 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL374309 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL218524 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL384217 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL192571 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL266944 | — | EC50 | > | 20000.0 | nM | - |