Assay Detail
Functional
CHEMBL909892
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Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.31 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384522 | — | — | 1 | 5.72 |
| CHEMBL261960 | — | — | 1 | 5.51 |
| CHEMBL217563 | — | — | 1 | 5.40 |
| CHEMBL368036 | — | — | 1 | 5.36 |
| CHEMBL217338 | — | — | 2 | 4.57 |
| CHEMBL419758 | — | — | 1 | - |
| CHEMBL217242 | — | — | 1 | - |
| CHEMBL424740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384522 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL261960 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL217563 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL368036 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL217338 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL419758 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL217338 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL217242 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL424740 | — | EC50 | > | 20000.0 | nM | - |