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Assay Detail

CHEMBL909964

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human SF1 by FRET-based peptide recruitment assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Steroidogenic factor 1 (CHEMBL4666)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.
Whitby RJ, Dixon S, Maloney PR, Delerive P, Goodwin BJ, Parks DJ, Willson TM.
J Med Chem (2006) 49 : 6652 -6655
PubMed 17154495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 7.03 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL384424 1 8.00
CHEMBL216179 1 7.96
CHEMBL214414 1 7.85
CHEMBL425623 1 7.52
CHEMBL384153 1 7.37
CHEMBL385911 1 7.27
CHEMBL409954 1 6.92
CHEMBL216778 1 6.89
CHEMBL214076 1 6.89
CHEMBL213816 1 6.89
CHEMBL410341 1 6.85
CHEMBL384937 1 6.77
CHEMBL217106 1 6.75
CHEMBL217156 1 6.25
CHEMBL386679 1 6.16
CHEMBL216620 1 6.10
CHEMBL214772 1 -
CHEMBL217746 1 -
CHEMBL214718 1 -
CHEMBL216893 1 -
CHEMBL216621 1 -
CHEMBL213659 1 -
CHEMBL384388 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL384424 EC50 = 10.0 nM 8.00
CHEMBL216179 EC50 = 11.0 nM 7.96
CHEMBL214414 EC50 = 14.0 nM 7.85
CHEMBL425623 EC50 = 30.0 nM 7.52
CHEMBL384153 EC50 = 43.0 nM 7.37
CHEMBL385911 EC50 = 54.0 nM 7.27
CHEMBL409954 EC50 = 120.0 nM 6.92
CHEMBL216778 EC50 = 130.0 nM 6.89
CHEMBL214076 EC50 = 130.0 nM 6.89
CHEMBL213816 EC50 = 130.0 nM 6.89
CHEMBL410341 EC50 = 140.0 nM 6.85
CHEMBL384937 EC50 = 170.0 nM 6.77
CHEMBL217106 EC50 = 180.0 nM 6.75
CHEMBL217156 EC50 = 560.0 nM 6.25
CHEMBL386679 EC50 = 700.0 nM 6.16
CHEMBL216620 EC50 = 800.0 nM 6.10
CHEMBL214772 EC50 > 10000.0 nM -
CHEMBL217746 EC50 > 10000.0 nM -
CHEMBL214718 EC50 > 10000.0 nM -
CHEMBL216893 EC50 > 10000.0 nM -
CHEMBL216621 EC50 > 10000.0 nM -
CHEMBL213659 EC50 > 10000.0 nM -
CHEMBL384388 EC50 > 10000.0 nM -