Assay Detail
Functional
CHEMBL909975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against NMDA receptor assessed as inhibition of NMDA-induced depolarization in mouse cortex
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.08 | 4.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310286 | — | — | 1 | 4.08 |
| CHEMBL217826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310286 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL217826 | — | IC50 | > | 80000.0 | nM | - |