Assay Detail
Functional
CHEMBL909976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against AMPA receptor assessed as inhibition of SAMPA-induced depolarization of mouse cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2096617) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Mus musculus |
Publication
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.83 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.70 |
| CHEMBL217826 | — | — | 1 | 5.46 |
| CHEMBL310286 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL217826 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL310286 | — | IC50 | = | 4600.0 | nM | 5.34 |