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Assay Detail

CHEMBL909984

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of maize HD1A
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zea mays
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Mai A, Massa S, Rotili D, Simeoni S, Ragno R, Botta G, Nebbioso A, Miceli M, Altucci L, Brosch G.
J Med Chem (2006) 49 : 6046 -6056
PubMed 17004718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 7.19 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 9.10
CHEMBL261831 1 8.22
CHEMBL217494 1 8.00
CHEMBL216875 1 7.96
CHEMBL387449 1 7.96
CHEMBL218348 1 7.77
CHEMBL214877 1 7.64
CHEMBL216834 1 7.55
CHEMBL218027 1 7.54
CHEMBL217449 1 7.52
CHEMBL217846 1 7.40
CHEMBL214837 1 7.37
CHEMBL216850 1 7.28
CHEMBL216065 1 7.28
CHEMBL384013 1 7.25
CHEMBL214533 1 7.11
CHEMBL217791 1 7.10
CHEMBL216064 1 6.98
CHEMBL216147 1 6.91
CHEMBL217192 1 6.89
CHEMBL98 VORINOSTAT 4.0 1 6.75
CHEMBL216118 1 6.67
CHEMBL217858 1 6.34
CHEMBL217539 1 6.01
CHEMBL413733 1 5.99
CHEMBL384062 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 0.8 nM 9.10
CHEMBL261831 IC50 = 6.0 nM 8.22
CHEMBL217494 IC50 = 10.0 nM 8.00
CHEMBL216875 IC50 = 11.0 nM 7.96
CHEMBL387449 IC50 = 11.0 nM 7.96
CHEMBL218348 IC50 = 17.0 nM 7.77
CHEMBL214877 IC50 = 23.0 nM 7.64
CHEMBL216834 IC50 = 28.0 nM 7.55
CHEMBL218027 IC50 = 29.0 nM 7.54
CHEMBL217449 IC50 = 30.0 nM 7.52
CHEMBL217846 IC50 = 40.0 nM 7.40
CHEMBL214837 IC50 = 43.0 nM 7.37
CHEMBL216850 IC50 = 52.0 nM 7.28
CHEMBL216065 IC50 = 52.0 nM 7.28
CHEMBL384013 IC50 = 56.0 nM 7.25
CHEMBL214533 IC50 = 77.0 nM 7.11
CHEMBL217791 IC50 = 80.0 nM 7.10
CHEMBL216064 IC50 = 105.0 nM 6.98
CHEMBL216147 IC50 = 122.0 nM 6.91
CHEMBL217192 IC50 = 130.0 nM 6.89
CHEMBL98 VORINOSTAT IC50 = 180.0 nM 6.75
CHEMBL216118 IC50 = 215.0 nM 6.67
CHEMBL217858 IC50 = 458.0 nM 6.34
CHEMBL217539 IC50 = 970.0 nM 6.01
CHEMBL413733 IC50 = 1020.0 nM 5.99
CHEMBL384062 IC50 = 52000.0 nM 4.28