Assay Detail
Functional
CHEMBL910422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.00 | 8.24 |
| Ki | 1 | 5.46 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.24 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.75 |
| CHEMBL216794 | — | — | 1 | 5.46 |
| CHEMBL376092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL59 | DOPAMINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL216794 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL376092 | — | EC50 | > | 10000.0 | nM | - |