Assay Detail
Binding
CHEMBL910434
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Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.73 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.44 |
| CHEMBL376092 | — | — | 1 | 7.57 |
| CHEMBL220189 | — | — | 1 | 6.63 |
| CHEMBL375596 | — | — | 1 | 5.54 |
| CHEMBL216794 | — | — | 1 | 5.46 |
| CHEMBL219185 | — | — | 1 | - |
| CHEMBL219179 | — | — | 1 | - |
| CHEMBL219261 | — | — | 1 | - |
| CHEMBL219182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL376092 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL220189 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL375596 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL216794 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL219185 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219179 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219261 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL219182 | — | Ki | > | 10000.0 | nM | - |