Assay Detail
Binding
CHEMBL910471
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Inhibition of Escherichia coli FPPS
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Farnesyl diphosphate synthase (CHEMBL1075078) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.93 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199858 | — | — | 1 | 6.16 |
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 5.96 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 5.96 |
| CHEMBL56073 | — | — | 1 | 5.89 |
| CHEMBL375618 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199858 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL56073 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL375618 | — | IC50 | = | 2100.0 | nM | 5.68 |