Assay Detail
Binding
CHEMBL910510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus topoisomerase 4 by decatenation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.36 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219216 | — | — | 1 | 7.00 |
| CHEMBL436512 | — | — | 1 | 6.70 |
| CHEMBL430 | GEMIFLOXACIN | 4.0 | 1 | 6.52 |
| CHEMBL219534 | — | — | 1 | 6.16 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 6.10 |
| CHEMBL220656 | — | — | 1 | 6.05 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219216 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL436512 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL430 | GEMIFLOXACIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL219534 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL220656 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1000.0 | nM | 6.00 |