Assay Detail
Functional
CHEMBL910576
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Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.81 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275925 | — | — | 1 | 8.00 |
| CHEMBL385064 | — | — | 1 | 8.00 |
| CHEMBL216895 | — | — | 1 | 7.70 |
| CHEMBL413443 | — | — | 1 | 7.30 |
| CHEMBL438288 | — | — | 1 | 6.75 |
| CHEMBL385623 | — | — | 1 | 6.41 |
| CHEMBL385873 | — | — | 1 | 5.28 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275925 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL385064 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL216895 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL413443 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL438288 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL385623 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL385873 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 8580.0 | nM | 5.07 |