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Assay Detail

CHEMBL910599

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Functional
Antiproliferative activity against HT29 cells by SRB assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Intermediate

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, structure-activity relationships, and antitumor studies of 2-benzoxazolyl hydrazones derived from alpha-(N)-acyl heteroaromatics.
Easmon J, Pürstinger G, Thies KS, Heinisch G, Hofmann J.
J Med Chem (2006) 49 : 6343 -6350
PubMed 17034140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.12 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL386573 1 7.40
CHEMBL386863 1 7.36
CHEMBL385309 1 6.96
CHEMBL386103 1 6.88
CHEMBL216960 1 6.72
CHEMBL384061 1 6.66
CHEMBL217229 1 6.57
CHEMBL214677 1 6.54
CHEMBL386236 1 6.47
CHEMBL215080 1 6.39
CHEMBL385553 1 6.19
CHEMBL384011 1 6.07
CHEMBL216889 1 5.84
CHEMBL217538 1 5.71
CHEMBL214409 1 5.67
CHEMBL406592 1 5.58
CHEMBL215178 1 5.32
CHEMBL217606 1 5.17
CHEMBL216191 1 5.16
CHEMBL216385 1 5.11
CHEMBL216374 1 4.69
CHEMBL217590 1 -
CHEMBL218398 1 -
CHEMBL217095 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL386573 IC50 = 40.0 nM 7.40
CHEMBL386863 IC50 = 44.0 nM 7.36
CHEMBL385309 IC50 = 110.0 nM 6.96
CHEMBL386103 IC50 = 132.0 nM 6.88
CHEMBL216960 IC50 = 190.0 nM 6.72
CHEMBL384061 IC50 = 219.0 nM 6.66
CHEMBL217229 IC50 = 270.0 nM 6.57
CHEMBL214677 IC50 = 290.0 nM 6.54
CHEMBL386236 IC50 = 340.0 nM 6.47
CHEMBL215080 IC50 = 409.0 nM 6.39
CHEMBL385553 IC50 = 645.0 nM 6.19
CHEMBL384011 IC50 = 851.0 nM 6.07
CHEMBL216889 IC50 = 1443.0 nM 5.84
CHEMBL217538 IC50 = 1930.0 nM 5.71
CHEMBL214409 IC50 = 2140.0 nM 5.67
CHEMBL406592 IC50 = 2640.0 nM 5.58
CHEMBL215178 IC50 = 4781.0 nM 5.32
CHEMBL217606 IC50 = 6770.0 nM 5.17
CHEMBL216191 IC50 = 6980.0 nM 5.16
CHEMBL216385 IC50 = 7760.0 nM 5.11
CHEMBL216374 IC50 = 20590.0 nM 4.69
CHEMBL217590 IC50 > 10000.0 nM -
CHEMBL218398 IC50 > 100000.0 nM -
CHEMBL217095 IC50 > 50000.0 nM -