Assay Detail
Binding
CHEMBL910638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from cloned human adrenergic alpha 1A receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.80 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 9.39 |
| CHEMBL215151 | — | — | 1 | 8.92 |
| CHEMBL217469 | — | — | 1 | 8.80 |
| CHEMBL383938 | — | — | 1 | 8.55 |
| CHEMBL439346 | — | — | 1 | 8.34 |
| CHEMBL214694 | — | — | 1 | 8.25 |
| CHEMBL214952 | — | — | 1 | 8.03 |
| CHEMBL214986 | — | — | 1 | 7.95 |
| CHEMBL217143 | — | — | 1 | 7.94 |
| CHEMBL214552 | — | — | 1 | 7.79 |
| CHEMBL218079 | — | — | 1 | 7.60 |
| CHEMBL215188 | — | — | 1 | 7.47 |
| CHEMBL385371 | — | — | 1 | 7.18 |
| CHEMBL214762 | — | — | 1 | 7.06 |
| CHEMBL215857 | — | — | 1 | 7.00 |
| CHEMBL436955 | — | — | 1 | 6.99 |
| CHEMBL214506 | — | — | 1 | 6.63 |
| CHEMBL218732 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Ki | = | 0.4074 | nM | 9.39 |
| CHEMBL215151 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL217469 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL383938 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL439346 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL214694 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL214952 | — | Ki | = | 9.333 | nM | 8.03 |
| CHEMBL214986 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL217143 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL214552 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL218079 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL215188 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL385371 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL214762 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL215857 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL436955 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL214506 | — | Ki | = | 234.42 | nM | 6.63 |
| CHEMBL218732 | — | Ki | = | 323.59 | nM | 6.49 |