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Assay Detail

CHEMBL910642

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Alpha-1D adrenergic receptor (CHEMBL223)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).
Pallavicini M, Budriesi R, Fumagalli L, Ioan P, Chiarini A, Bolchi C, Ugenti MP, Colleoni S, Gobbi M, Valoti E.
J Med Chem (2006) 49 : 7140 -7149
PubMed 17125266 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 7.33 9.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215421 1 9.29
CHEMBL215151 1 8.47
CHEMBL217469 1 8.18
CHEMBL214986 1 7.98
CHEMBL383938 1 7.84
CHEMBL214694 1 7.82
CHEMBL217143 1 7.80
CHEMBL439346 1 7.65
CHEMBL214952 1 7.54
CHEMBL214552 1 7.27
CHEMBL385371 1 6.83
CHEMBL215857 1 6.69
CHEMBL214762 1 6.67
CHEMBL436955 1 6.53
CHEMBL218079 1 6.47
CHEMBL214506 1 6.44
CHEMBL215188 1 6.38
CHEMBL218732 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215421 Ki = 0.5129 nM 9.29
CHEMBL215151 Ki = 3.388 nM 8.47
CHEMBL217469 Ki = 6.607 nM 8.18
CHEMBL214986 Ki = 10.47 nM 7.98
CHEMBL383938 Ki = 14.45 nM 7.84
CHEMBL214694 Ki = 15.14 nM 7.82
CHEMBL217143 Ki = 15.85 nM 7.80
CHEMBL439346 Ki = 22.39 nM 7.65
CHEMBL214952 Ki = 28.84 nM 7.54
CHEMBL214552 Ki = 53.7 nM 7.27
CHEMBL385371 Ki = 147.91 nM 6.83
CHEMBL215857 Ki = 204.17 nM 6.69
CHEMBL214762 Ki = 213.8 nM 6.67
CHEMBL436955 Ki = 295.12 nM 6.53
CHEMBL218079 Ki = 338.84 nM 6.47
CHEMBL214506 Ki = 363.08 nM 6.44
CHEMBL215188 Ki = 416.87 nM 6.38
CHEMBL218732 Ki = 954.99 nM 6.02