Assay Detail
Functional
CHEMBL910654
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Antiplasmodial activity against Plasmodium falciparum NF54
62
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.08 | 7.89 |
| MIC | 31 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218854 | — | — | 2 | 7.89 |
| CHEMBL375375 | — | — | 2 | 7.85 |
| CHEMBL219967 | — | — | 2 | 7.41 |
| CHEMBL219009 | — | — | 2 | 7.19 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.97 |
| CHEMBL219189 | — | — | 2 | 6.86 |
| CHEMBL219031 | — | — | 2 | 6.57 |
| CHEMBL218312 | — | — | 2 | 6.54 |
| CHEMBL219398 | — | — | 2 | 6.37 |
| CHEMBL219436 | — | — | 2 | 6.01 |
| CHEMBL376236 | — | — | 2 | 5.99 |
| CHEMBL376916 | — | — | 2 | 5.98 |
| CHEMBL219537 | — | — | 2 | 5.90 |
| CHEMBL222017 | — | — | 2 | 5.89 |
| CHEMBL219109 | — | — | 2 | 5.82 |
| CHEMBL219395 | — | — | 2 | 5.78 |
| CHEMBL425990 | — | — | 2 | 5.78 |
| CHEMBL219517 | — | — | 2 | 5.74 |
| CHEMBL375612 | — | — | 2 | 5.74 |
| CHEMBL219488 | — | — | 2 | 5.70 |
| CHEMBL220134 | — | — | 2 | 5.67 |
| CHEMBL218530 | — | — | 2 | 5.66 |
| CHEMBL373799 | — | — | 2 | 5.63 |
| CHEMBL218897 | — | — | 2 | 5.58 |
| CHEMBL385783 | — | — | 2 | 5.54 |
| CHEMBL222016 | — | — | 2 | 5.52 |
| CHEMBL218389 | — | — | 2 | 5.51 |
| CHEMBL374418 | — | — | 2 | 5.49 |
| CHEMBL219444 | — | — | 2 | 5.39 |
| CHEMBL219397 | — | — | 2 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218854 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL375375 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL219967 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL219009 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL219189 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL219031 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL218312 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL219398 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL219436 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL376236 | — | IC50 | = | 1031.0 | nM | 5.99 |
| CHEMBL376916 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL219537 | — | IC50 | = | 1272.0 | nM | 5.90 |
| CHEMBL222017 | — | IC50 | = | 1286.0 | nM | 5.89 |
| CHEMBL219109 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL219395 | — | IC50 | = | 1678.0 | nM | 5.78 |
| CHEMBL425990 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL375612 | — | IC50 | = | 1812.0 | nM | 5.74 |
| CHEMBL219517 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL219488 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL220134 | — | IC50 | = | 2144.0 | nM | 5.67 |
| CHEMBL218530 | — | IC50 | = | 2193.0 | nM | 5.66 |
| CHEMBL373799 | — | IC50 | = | 2327.0 | nM | 5.63 |
| CHEMBL218897 | — | IC50 | = | 2647.0 | nM | 5.58 |
| CHEMBL385783 | — | IC50 | = | 2917.0 | nM | 5.54 |
| CHEMBL222016 | — | IC50 | = | 3031.0 | nM | 5.52 |
| CHEMBL218389 | — | IC50 | = | 3074.0 | nM | 5.51 |
| CHEMBL374418 | — | IC50 | = | 3271.0 | nM | 5.49 |
| CHEMBL219444 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL219397 | — | IC50 | = | 6154.0 | nM | 5.21 |
| CHEMBL218531 | — | IC50 | = | 7153.0 | nM | 5.15 |
| CHEMBL374418 | — | MIC | = | 4280.0 | nM | - |
| CHEMBL219009 | — | MIC | = | 680.0 | nM | - |
| CHEMBL218854 | — | MIC | = | 260.0 | nM | - |
| CHEMBL218312 | — | MIC | = | 5880.0 | nM | - |
| CHEMBL425990 | — | MIC | = | 3110.0 | nM | - |
| CHEMBL376916 | — | MIC | = | 1160.0 | nM | - |
| CHEMBL220134 | — | MIC | = | 3250.0 | nM | - |
| CHEMBL219395 | — | MIC | = | 3110.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | MIC | = | 390.0 | nM | - |
| CHEMBL218389 | — | MIC | = | 13810.0 | nM | - |
| CHEMBL219189 | — | MIC | = | 270.0 | nM | - |
| CHEMBL373799 | — | MIC | = | 5650.0 | nM | - |
| CHEMBL219517 | — | MIC | = | 2480.0 | nM | - |
| CHEMBL219031 | — | MIC | = | 540.0 | nM | - |
| CHEMBL219397 | — | MIC | = | 10390.0 | nM | - |
| CHEMBL219398 | — | MIC | = | 1300.0 | nM | - |
| CHEMBL375375 | — | MIC | = | 280.0 | nM | - |
| CHEMBL376236 | — | MIC | = | 2020.0 | nM | - |
| CHEMBL218530 | — | MIC | = | 9450.0 | nM | - |