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Assay Detail

CHEMBL910697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Bifunctional epoxide hydrolase 2 (CHEMBL2409)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
Hwang SH, Morisseau C, Do Z, Hammock BD.
Bioorg Med Chem Lett (2006) 16 : 5773 -5777
PubMed 16949285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.84 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL221793 1 9.30
CHEMBL374322 1 9.30
CHEMBL376647 1 9.30
CHEMBL221737 1 9.22
CHEMBL374730 1 9.15
CHEMBL221014 1 9.05
CHEMBL220908 1 9.00
CHEMBL221015 1 8.92
CHEMBL222161 1 8.70
CHEMBL438983 1 8.54
CHEMBL373655 1 7.52
CHEMBL222080 1 7.00
CHEMBL426555 1 7.00
CHEMBL222160 1 6.66
CHEMBL221792 1 6.23
CHEMBL434749 1 6.03
CHEMBL221446 1 5.92
CHEMBL217942 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL221793 IC50 = 0.5 nM 9.30
CHEMBL374322 IC50 = 0.5 nM 9.30
CHEMBL376647 IC50 = 0.5 nM 9.30
CHEMBL221737 IC50 = 0.6 nM 9.22
CHEMBL374730 IC50 = 0.7 nM 9.15
CHEMBL221014 IC50 = 0.9 nM 9.05
CHEMBL220908 IC50 = 1.0 nM 9.00
CHEMBL221015 IC50 = 1.2 nM 8.92
CHEMBL222161 IC50 = 2.0 nM 8.70
CHEMBL438983 IC50 = 2.9 nM 8.54
CHEMBL373655 IC50 = 30.0 nM 7.52
CHEMBL222080 IC50 = 100.0 nM 7.00
CHEMBL426555 IC50 = 100.0 nM 7.00
CHEMBL222160 IC50 = 220.0 nM 6.66
CHEMBL221792 IC50 = 590.0 nM 6.23
CHEMBL434749 IC50 = 940.0 nM 6.03
CHEMBL221446 IC50 = 1200.0 nM 5.92
CHEMBL217942 IC50 = 50500.0 nM 4.30