Assay Detail
Functional
CHEMBL910779
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Inhibition of growth in 1A9 cell line after 72 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.38 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219213 | — | — | 1 | 10.15 |
| CHEMBL373681 | — | — | 1 | 9.49 |
| CHEMBL435147 | — | — | 1 | 8.74 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.32 |
| CHEMBL4649905 | — | — | 1 | 8.15 |
| CHEMBL4649917 | — | — | 1 | 7.91 |
| CHEMBL4649902 | — | — | 1 | 7.89 |
| CHEMBL374763 | — | — | 1 | 7.86 |
| CHEMBL435148 | — | — | 1 | 7.72 |
| CHEMBL4649906 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219213 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL373681 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL435147 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4649905 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4649917 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL4649902 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL374763 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL435148 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4649906 | — | IC50 | = | 24.6 | nM | 7.61 |