Assay Detail
Functional
CHEMBL910782
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of growth in epothilone A resistant 1A9-A8 T-beta-274I mutant cell line after 72 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.80 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373681 | — | — | 1 | 9.57 |
| CHEMBL219213 | — | — | 1 | 9.36 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.67 |
| CHEMBL4649905 | — | — | 1 | 7.58 |
| CHEMBL4649917 | — | — | 1 | 7.33 |
| CHEMBL435148 | — | — | 1 | 7.18 |
| CHEMBL374763 | — | — | 1 | 6.86 |
| CHEMBL435147 | — | — | 1 | 6.83 |
| CHEMBL4649902 | — | — | 1 | - |
| CHEMBL4649906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373681 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL219213 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL4649905 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL4649917 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL435148 | — | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL374763 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL435147 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4649902 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL4649906 | — | IC50 | > | 300.0 | nM | - |