Assay Detail
Binding
CHEMBL910892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215803 | — | — | 1 | 9.00 |
| CHEMBL141247 | — | — | 1 | 6.91 |
| CHEMBL336242 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215803 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL141247 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL336242 | — | IC50 | = | 1800.0 | nM | 5.75 |