Assay Detail
Binding
CHEMBL911248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.63 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.30 |
| CHEMBL387250 | — | — | 1 | 8.10 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.68 |
| CHEMBL217299 | DOXANTHRINE | — | 1 | 7.66 |
| CHEMBL384046 | — | — | 1 | 6.57 |
| CHEMBL1203924 | — | — | 1 | 6.48 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | - |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | - |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL387250 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL217299 | DOXANTHRINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL384046 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1203924 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL59 | DOPAMINE | Ki | - | — | - | |
| CHEMBL71 | CHLORPROMAZINE | Ki | - | — | - | |
| CHEMBL240773 | QUINPIROLE | Ki | - | — | - |