Assay Detail
Binding
CHEMBL911286
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Inhibition of catalytic domain of human recombinant CA IX
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.27 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6685 | — | — | 1 | 7.85 |
| CHEMBL6633 | — | — | 1 | 7.80 |
| CHEMBL6919 | — | — | 1 | 7.68 |
| CHEMBL6784 | — | — | 1 | 7.66 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.62 |
| CHEMBL7146 | — | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL6753 | — | — | 1 | 7.52 |
| CHEMBL360356 | — | — | 1 | 7.52 |
| CHEMBL266026 | — | — | 1 | 7.51 |
| CHEMBL6705 | — | — | 1 | 7.48 |
| CHEMBL7087 | — | — | 1 | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL268439 | — | — | 1 | 7.42 |
| CHEMBL266240 | — | — | 1 | 7.41 |
| CHEMBL265674 | — | — | 1 | 7.39 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.34 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.33 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.24 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.99 |
| CHEMBL176495 | — | — | 1 | 6.75 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.62 |
| CHEMBL6853 | — | — | 1 | 6.61 |
| CHEMBL7092 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6685 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL6633 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL6919 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL6784 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL7146 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL414 | CARZENIDE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL6753 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL360356 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL266026 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL6705 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL7087 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL268439 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL266240 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL265674 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL26 | SULPIRIDE | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL419 | MAFENIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL176495 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL6853 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL7092 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL6724 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL268177 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL7204 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 460.0 | nM | 6.34 |