Assay Detail
Functional
CHEMBL911294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glucose output in glucagon challenged rat hepatocytes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.81 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373749 | — | — | 1 | 6.25 |
| CHEMBL218287 | — | — | 1 | 6.16 |
| CHEMBL217994 | — | — | 1 | 6.00 |
| CHEMBL217956 | — | — | 1 | 5.96 |
| CHEMBL374945 | — | — | 1 | 5.89 |
| CHEMBL218714 | — | — | 1 | 5.85 |
| CHEMBL219059 | — | — | 1 | 5.82 |
| CHEMBL217903 | — | — | 1 | 5.80 |
| CHEMBL430503 | — | — | 1 | 5.58 |
| CHEMBL386015 | — | — | 1 | 5.44 |
| CHEMBL139461 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373749 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL218287 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL217994 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL217956 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL374945 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL218714 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL219059 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL217903 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL430503 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL386015 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL139461 | — | IC50 | = | 7000.0 | nM | 5.16 |