Assay Detail
Binding
CHEMBL911296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli K12 Mur A in presence of UNAG
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (CHEMBL1984) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.23 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1757 | FOSFOMYCIN | 4.0 | 1 | 6.93 |
| CHEMBL1257707 | CNICIN | — | 1 | 4.78 |
| CHEMBL374146 | CYNAROPICRIN | — | 1 | 4.71 |
| CHEMBL221283 | EUPATORIOPICRIN | — | 1 | 4.49 |
| CHEMBL86416 | COSTUNOLIDE | — | 2 | - |
| CHEMBL218788 | — | — | 1 | - |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | — | 1 | - |
| CHEMBL136356 | HELENINE | — | 1 | - |
| CHEMBL4298697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1757 | FOSFOMYCIN | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1257707 | CNICIN | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL374146 | CYNAROPICRIN | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL221283 | EUPATORIOPICRIN | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL86416 | COSTUNOLIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL218788 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL86416 | COSTUNOLIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL136356 | HELENINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL4298697 | — | IC50 | > | 50000.0 | nM | - |