Assay Detail
Binding
CHEMBL911322
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Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.12 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220566 | — | — | 1 | 7.96 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.89 |
| CHEMBL385330 | — | — | 1 | 7.85 |
| CHEMBL223637 | — | — | 1 | 7.82 |
| CHEMBL426567 | — | — | 1 | 6.97 |
| CHEMBL375594 | — | — | 1 | 6.84 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | — | 1 | 6.24 |
| CHEMBL3706857 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220566 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL385330 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL223637 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL426567 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL375594 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL3706857 | — | Ki | = | 4500.0 | nM | 5.35 |