Assay Detail
Binding
CHEMBL911349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PLK1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219899 | — | — | 1 | 6.90 |
| CHEMBL220032 | — | — | 1 | 6.60 |
| CHEMBL219711 | — | — | 1 | 6.20 |
| CHEMBL222312 | — | — | 1 | 6.20 |
| CHEMBL373751 | GSK-319347A | — | 1 | 6.10 |
| CHEMBL375787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219899 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL220032 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL219711 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL222312 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL373751 | GSK-319347A | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL375787 | — | IC50 | < | 10000.0 | nM | - |