Assay Detail
Binding
CHEMBL911376
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Inhibition of MMP2
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.02 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373532 | — | — | 1 | 8.30 |
| CHEMBL375418 | — | — | 1 | 7.89 |
| CHEMBL434567 | — | — | 1 | 7.41 |
| CHEMBL219105 | — | — | 1 | 7.19 |
| CHEMBL387202 | — | — | 1 | 6.82 |
| CHEMBL221857 | — | — | 1 | 6.70 |
| CHEMBL426388 | — | — | 1 | 6.46 |
| CHEMBL219104 | — | — | 1 | 6.35 |
| CHEMBL221698 | — | — | 1 | 6.02 |
| CHEMBL220975 | — | — | 1 | - |
| CHEMBL373853 | — | — | 1 | - |
| CHEMBL221120 | — | — | 1 | - |
| CHEMBL220501 | — | — | 1 | - |
| CHEMBL218586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373532 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL375418 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL434567 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL219105 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL387202 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL221857 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL426388 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL219104 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL221698 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL220975 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL373853 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221120 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL220501 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL218586 | — | IC50 | > | 5000.0 | nM | - |