Assay Detail
Binding
CHEMBL911377
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Inhibition of MMP3
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.89 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375418 | — | — | 1 | 6.35 |
| CHEMBL373532 | — | — | 1 | 5.92 |
| CHEMBL434567 | — | — | 1 | 5.40 |
| CHEMBL220975 | — | — | 1 | - |
| CHEMBL221857 | — | — | 1 | - |
| CHEMBL219105 | — | — | 1 | - |
| CHEMBL387202 | — | — | 1 | - |
| CHEMBL221698 | — | — | 1 | - |
| CHEMBL426388 | — | — | 1 | - |
| CHEMBL373853 | — | — | 1 | - |
| CHEMBL221120 | — | — | 1 | - |
| CHEMBL220501 | — | — | 1 | - |
| CHEMBL218586 | — | — | 1 | - |
| CHEMBL219104 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375418 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL373532 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL434567 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL220975 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL221857 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL219105 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL387202 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221698 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL426388 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL373853 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221120 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL220501 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL218586 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL219104 | — | IC50 | > | 5000.0 | nM | - |