Assay Detail
Functional
CHEMBL911502
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Antiproliferative activity against human 293T cells after 48 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.96 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384281 | — | — | 1 | 5.09 |
| CHEMBL215613 | — | — | 1 | 5.01 |
| CHEMBL16947 | WR-190433 | — | 1 | 4.86 |
| CHEMBL425789 | — | — | 1 | 4.86 |
| CHEMBL212650 | — | — | 1 | - |
| CHEMBL380270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384281 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL215613 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL16947 | WR-190433 | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL425789 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL212650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL380270 | — | IC50 | > | 100000.0 | nM | - |