Assay Detail
Functional
CHEMBL911541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of human PPARdelta in CV1 cells by luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213315 | — | — | 1 | 9.00 |
| CHEMBL214921 | — | — | 1 | 8.70 |
| CHEMBL377660 | — | — | 1 | 8.30 |
| CHEMBL212911 | — | — | 1 | 8.30 |
| CHEMBL215701 | — | — | 1 | 8.22 |
| CHEMBL378068 | — | — | 1 | 8.15 |
| CHEMBL214026 | — | — | 1 | 8.10 |
| CHEMBL215127 | — | — | 1 | 7.60 |
| CHEMBL215245 | — | — | 1 | 7.47 |
| CHEMBL215582 | — | — | 1 | 7.35 |
| CHEMBL213314 | — | — | 1 | 7.33 |
| CHEMBL212023 | — | — | 1 | 7.28 |
| CHEMBL212591 | — | — | 1 | 7.16 |
| CHEMBL213361 | — | — | 1 | 7.14 |
| CHEMBL215126 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213315 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL214921 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL377660 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL212911 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL215701 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL378068 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL214026 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL215127 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL215245 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL215582 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL213314 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL212023 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL212591 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL213361 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL215126 | — | EC50 | = | 339.0 | nM | 6.47 |