Assay Detail
Functional
CHEMBL911615
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Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.83 | 5.89 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 5.89 |
| CHEMBL1427 | HYPOXANTHINE | — | 1 | 5.38 |
| CHEMBL374107 | 8-AZAGUANINE | — | 1 | 5.18 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 4.67 |
| CHEMBL219568 | GUANINE | 3.0 | 1 | 4.45 |
| CHEMBL226396 | 6-CHLOROGUANINE | — | 1 | 4.17 |
| CHEMBL219416 | — | — | 1 | 4.05 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | - |
| CHEMBL219341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1427 | HYPOXANTHINE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL374107 | 8-AZAGUANINE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL219568 | GUANINE | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL226396 | 6-CHLOROGUANINE | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL219416 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1467 | ALLOPURINOL | IC50 | >= | 150000.0 | nM | - |
| CHEMBL219341 | — | Activity | - | — | - |