Assay Detail
Functional
CHEMBL911782
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Antiproliferative activity against mouse L1210 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.20 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL410661 | — | — | 1 | 8.01 |
| CHEMBL387263 | — | — | 1 | 7.96 |
| CHEMBL217472 | — | — | 1 | 7.96 |
| CHEMBL217301 | — | — | 1 | 7.92 |
| CHEMBL217797 | — | — | 1 | 7.75 |
| CHEMBL217297 | — | — | 1 | 7.70 |
| CHEMBL217256 | — | — | 1 | 7.70 |
| CHEMBL426514 | — | — | 1 | 7.66 |
| CHEMBL217134 | — | — | 1 | 7.40 |
| CHEMBL218188 | — | — | 1 | 7.35 |
| CHEMBL386381 | — | — | 1 | 7.03 |
| CHEMBL385640 | — | — | 1 | 7.00 |
| CHEMBL218241 | — | — | 1 | 7.00 |
| CHEMBL217838 | — | — | 1 | 6.58 |
| CHEMBL217075 | — | — | 1 | 6.43 |
| CHEMBL384779 | — | — | 1 | 6.40 |
| CHEMBL385766 | — | — | 1 | 6.23 |
| CHEMBL385531 | — | — | 1 | 5.74 |
| CHEMBL384313 | — | — | 1 | 5.64 |
| CHEMBL409465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL410661 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL387263 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL217472 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL217301 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL217797 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL217297 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL217256 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL426514 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL217134 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL218188 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL386381 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL385640 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL218241 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL217838 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL217075 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL384779 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL385766 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL385531 | — | IC50 | = | 1808.0 | nM | 5.74 |
| CHEMBL384313 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL409465 | — | IC50 | > | 10000.0 | nM | - |