Assay Detail
Binding
CHEMBL911909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GalE by HPAEC assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.58 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 7.85 |
| CHEMBL1289 | HALOPROGIN | 4.0 | 1 | 6.30 |
| CHEMBL83747 | PSAMMAPLIN A | — | 1 | 5.44 |
| CHEMBL374772 | — | — | 1 | 4.92 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 4.85 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 4.12 |
| CHEMBL220636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1289 | HALOPROGIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL83747 | PSAMMAPLIN A | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL374772 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL220636 | — | IC50 | - | — | - |