Assay Detail
ADMET
CHEMBL911913
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Cytotoxicity against CHO-K1 cells by Alamar blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.34 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | 4.0 | 1 | 6.22 |
| CHEMBL83747 | PSAMMAPLIN A | — | 1 | 6.05 |
| CHEMBL220636 | — | — | 1 | 5.22 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.21 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 5.07 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 4.25 |
| CHEMBL374772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL83747 | PSAMMAPLIN A | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL220636 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL51085 | EBSELEN | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL411 | DIETHYLSTILBESTROL | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL456 | ETHACRYNIC ACID | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL374772 | — | EC50 | > | 100000.0 | nM | - |