Assay Detail
Binding
CHEMBL911915
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Binding affinity to recombinant XIAP BIR3 by FP assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.12 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221313 | — | — | 1 | 6.75 |
| CHEMBL221256 | — | — | 1 | 6.42 |
| CHEMBL221137 | EMBELIN | — | 1 | 6.40 |
| CHEMBL375784 | — | — | 1 | 6.32 |
| CHEMBL373766 | — | — | 1 | 6.24 |
| CHEMBL221647 | — | — | 1 | 6.15 |
| CHEMBL221598 | — | — | 1 | 5.90 |
| CHEMBL221599 | — | — | 1 | 5.89 |
| CHEMBL222173 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221313 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL221256 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL221137 | EMBELIN | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL375784 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL373766 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL221647 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL221598 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL221599 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL222173 | — | Ki | = | 10400.0 | nM | 4.98 |