Assay Detail
Functional
CHEMBL911930
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Growth inhibition in HUVEC
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.20 | 9.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | — | 1 | 9.30 |
| CHEMBL221540 | — | — | 1 | 9.00 |
| CHEMBL221697 | — | — | 1 | 6.30 |
| CHEMBL221538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL221540 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL221697 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL221538 | — | Activity | - | — | - |