Assay Detail
Binding
CHEMBL911981
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Inhibition of DLK
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.38 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416056 | — | — | 1 | 6.44 |
| CHEMBL386636 | — | — | 1 | 6.31 |
| CHEMBL148471 | — | — | 1 | - |
| CHEMBL221536 | — | — | 1 | - |
| CHEMBL357490 | — | — | 1 | - |
| CHEMBL374581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416056 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL386636 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL148471 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL221536 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL357490 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL374581 | — | IC50 | > | 1000.0 | nM | - |