Assay Detail
Binding
CHEMBL912374
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Inhibition of human thymidylate synthase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Antibacterial agent discovery using thymidylate synthase biolibrary screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.57 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389051 | — | — | 1 | 7.52 |
| CHEMBL386442 | — | — | 1 | 6.40 |
| CHEMBL385891 | — | — | 1 | 5.50 |
| CHEMBL387007 | — | — | 1 | 5.33 |
| CHEMBL386282 | — | — | 1 | 5.24 |
| CHEMBL67116 | — | — | 1 | 4.52 |
| CHEMBL217760 | — | — | 1 | 4.47 |
| CHEMBL217227 | — | — | 1 | - |
| CHEMBL303171 | — | — | 1 | - |
| CHEMBL216560 | — | — | 1 | - |
| CHEMBL215133 | — | — | 1 | - |
| CHEMBL214872 | — | — | 1 | - |
| CHEMBL414689 | — | — | 1 | - |
| CHEMBL411871 | — | — | 1 | - |
| CHEMBL385296 | — | — | 1 | - |
| CHEMBL386685 | — | — | 1 | - |
| CHEMBL217000 | — | — | 1 | - |
| CHEMBL216675 | — | — | 1 | - |
| CHEMBL217765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389051 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL386442 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL385891 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL387007 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL386282 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL67116 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL217760 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL217227 | — | Ki | > | 245000.0 | nM | - |
| CHEMBL303171 | — | Ki | > | 402000.0 | nM | - |
| CHEMBL216560 | — | Ki | > | 245000.0 | nM | - |
| CHEMBL215133 | — | Ki | > | 132000.0 | nM | - |
| CHEMBL214872 | — | Ki | > | 245000.0 | nM | - |
| CHEMBL414689 | — | Ki | - | — | - | |
| CHEMBL411871 | — | Ki | > | 132000.0 | nM | - |
| CHEMBL385296 | — | Ki | > | 132000.0 | nM | - |
| CHEMBL386685 | — | Ki | > | 132000.0 | nM | - |
| CHEMBL217000 | — | Ki | > | 120000.0 | nM | - |
| CHEMBL216675 | — | Ki | > | 245000.0 | nM | - |
| CHEMBL217765 | — | Ki | > | 132000.0 | nM | - |