Assay Detail
Binding
CHEMBL912396
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Inhibition of Leishmania major recombinant 24-SMT
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cycloartenol-C-24-methyltransferase (CHEMBL4264) ↗| Type | SINGLE PROTEIN |
| Organism | Arabidopsis thaliana |
Publication
Evaluation of azasterols as anti-parasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 5.75 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214240 | — | — | 1 | 7.55 |
| CHEMBL217534 | — | — | 1 | 5.40 |
| CHEMBL218731 | — | — | 1 | 4.31 |
| CHEMBL217116 | — | — | 1 | - |
| CHEMBL265536 | — | — | 1 | - |
| CHEMBL384947 | — | — | 1 | - |
| CHEMBL215209 | — | — | 1 | - |
| CHEMBL425637 | — | — | 1 | - |
| CHEMBL386179 | — | — | 1 | - |
| CHEMBL425078 | — | — | 1 | - |
| CHEMBL385681 | — | — | 1 | - |
| CHEMBL215430 | — | — | 1 | - |
| CHEMBL217066 | — | — | 1 | - |
| CHEMBL385261 | — | — | 1 | - |
| CHEMBL217129 | — | — | 1 | - |
| CHEMBL262278 | — | — | 1 | - |
| CHEMBL424916 | — | — | 1 | - |
| CHEMBL215774 | — | — | 1 | - |
| CHEMBL385174 | — | — | 1 | - |
| CHEMBL214526 | — | — | 1 | - |
| CHEMBL216562 | — | — | 1 | - |
| CHEMBL217279 | — | — | 1 | - |
| CHEMBL218239 | — | — | 1 | - |
| CHEMBL387268 | — | — | 1 | - |
| CHEMBL217321 | — | — | 1 | - |
| CHEMBL218237 | — | — | 1 | - |
| CHEMBL213606 | — | — | 1 | - |
| CHEMBL386433 | — | — | 1 | - |
| CHEMBL217841 | — | — | 1 | - |
| CHEMBL387463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214240 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL217534 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL218731 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL384947 | — | IC50 | - | — | - | |
| CHEMBL216713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL265536 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217116 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL384335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL385193 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL386390 | — | IC50 | - | — | - | |
| CHEMBL217317 | — | IC50 | - | — | - | |
| CHEMBL216551 | — | IC50 | - | — | - | |
| CHEMBL217512 | — | IC50 | - | — | - | |
| CHEMBL384557 | — | IC50 | - | — | - | |
| CHEMBL213605 | — | IC50 | - | — | - | |
| CHEMBL217185 | — | IC50 | - | — | - | |
| CHEMBL217523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL384383 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217554 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL384016 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL437714 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217006 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL385174 | — | IC50 | - | — | - | |
| CHEMBL387463 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217841 | — | IC50 | - | — | - | |
| CHEMBL386433 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL218237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL387268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL218239 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL216562 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL214526 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL215209 | — | IC50 | - | — | - | |
| CHEMBL215774 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL424916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL262278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217129 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL385261 | — | IC50 | - | — | - | |
| CHEMBL217066 | — | IC50 | - | — | - | |
| CHEMBL215430 | — | IC50 | - | — | - | |
| CHEMBL385681 | — | IC50 | - | — | - | |
| CHEMBL425078 | — | IC50 | - | — | - | |
| CHEMBL386179 | — | IC50 | - | — | - | |
| CHEMBL425637 | — | IC50 | - | — | - |