Assay Detail
Functional
CHEMBL912415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human dopamine D4.4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.48 | 8.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.00 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.77 |
| CHEMBL1203924 | — | — | 2 | 7.68 |
| CHEMBL387250 | — | — | 1 | 7.02 |
| CHEMBL217299 | DOXANTHRINE | — | 1 | 6.96 |
| CHEMBL384046 | — | — | 1 | 6.64 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL59 | DOPAMINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL25856 | DIHYDREXIDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1203924 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL387250 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL217299 | DOXANTHRINE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL384046 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL71 | CHLORPROMAZINE | EC50 | - | — | - | |
| CHEMBL62 | SCH-23390 | EC50 | - | — | - | |
| CHEMBL1203924 | — | Activity | - | — | - |