Assay Detail
Functional
CHEMBL912431
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Antiproliferative activity against K562 cell line
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.17 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425089 | — | — | 1 | 4.30 |
| CHEMBL215072 | — | — | 1 | 4.26 |
| CHEMBL215205 | — | — | 1 | 4.21 |
| CHEMBL217836 | — | — | 1 | 4.15 |
| CHEMBL217734 | — | — | 1 | 4.10 |
| CHEMBL387068 | — | — | 1 | 4.00 |
| CHEMBL384625 | — | — | 1 | - |
| CHEMBL280074 | OLOMOUCINE | — | 1 | - |
| CHEMBL428639 | — | — | 1 | - |
| CHEMBL383939 | — | — | 1 | - |
| CHEMBL425975 | — | — | 1 | - |
| CHEMBL216673 | — | — | 1 | - |
| CHEMBL214475 | — | — | 1 | - |
| CHEMBL386422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425089 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL215072 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL215205 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL217836 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL217734 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL387068 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL384625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 145000.0 | nM | - |
| CHEMBL428639 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL383939 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL425975 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL216673 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL214475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL386422 | — | IC50 | > | 100000.0 | nM | - |