Assay Detail
Binding
CHEMBL912440
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Inhibition of CDK4/Cyclin D1 in presence of 100 uM ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.52 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215205 | — | — | 1 | 4.87 |
| CHEMBL387068 | — | — | 1 | 4.80 |
| CHEMBL214475 | — | — | 1 | 4.25 |
| CHEMBL217734 | — | — | 1 | 4.16 |
| CHEMBL384625 | — | — | 1 | - |
| CHEMBL428639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215205 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL387068 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL214475 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL217734 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL384625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL428639 | — | IC50 | > | 100000.0 | nM | - |